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Background Histology information management relies on complex knowledge derived from morphological tissue analyses. These approaches have not significantly facilitated the general integration of tissue- and molecular-level knowledge across the board in support of a systematic classification of tissue function, as well as the coherent multi-scale study of physiology. Our work aims to support.
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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix.
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Bone and cartilage injury is common, tissue engineered scaffolds are potential means to repair. Because most of the scaffold materials used in bone and cartilage tissue engineering are bio-inert, it is necessary to increase the cellular adhesion ability of during tissue engineering reconstruction. The Arginine - Glycine - Aspartic acid (Arg-Gly-Asp, RGD) peptide family is considered as a.
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Author summary Much like many ballet dances that are choreographed by combining the same movements in different ways, tissue morphogenesis relies on combinations of highly conserved sub- to multi-cellular behaviors, or motifs, such as cell division, death and intercalation. Algorithms for systematic mapping of morphogenetic motifs are essential for making the most of rapidly accumulating live.
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2.1 Alginate. Alginate is a common biopolymer derived primarily from brown algae and bacteria (Lee and Mooney, 2012).It is a polysaccharide with ionic and hydrophobic properties, composed of two uronic acids: M (1-4)-linked β-D-mannuronic acid (M) and G α-l-guluronic acid (G) monomers (Sun and Tan, 2013) as showed in Figure 1.Alginate is non-immunogenic, biocompatible, and biodegradable.
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Cellular mechanotransduction is an important biological process in living organisms. It was first studied based on the Wolff's Law on mechanical load in tissue homeostasis and has extended to.
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We present Tissue Schematics, a computational and conceptual framework for using high-parameter imaging data to map how tissues are formed by the assembly of cellular neighborhoods into tissue motifs. Applying our framework to human lymphoid tissues and the colorectal cancer immune-tumor microenvironment suggests mechanistic insights into the specific biology of these tissues, as well as.
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